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San Luis vs. Club Leon prediction, odds, Liga MX picks [3/21/2026]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get San Luis vs Club Leon predictions for Liga MX Saturday.
Atletico San Luis and Club Leon will lock horns in the Liga MX playoffs at Estadio Alfonso Lastras on Saturday, with kickoff at 9:00 PM ET.
Based on the latest simulation results, Dimers' advanced Liga MX model predicts San Luis as the most likely winner of the Atletico San Luis vs. Club Leon game.
This article offers a closer look at Saturday's matchup, including best bets and picks.
Atletico San Luis vs. Club Leon prediction: Who will win?
Using innovative machine learning and data, we have simulated the outcome of Saturday's Liga MX game between Atletico San Luis and Club Leon 10,000 times as part of our Liga MX predictions coverage.
Our independent predictive model currently indicates a 40.1% chance of Atletico San Luis winning, a 35.5% chance for Club Leon, and a 24.4% chance of a draw.
Additionally, the over/under total of 2.5 goals has a 57% chance of going over, according to our model.
Atletico San Luis vs. Club Leon odds
We have researched the best Liga MX odds in America for this game, which are listed here:
Moneyline
| Atletico San Luis | Club Leon | Draw |
|---|---|---|
| +115 | +210 | +270 |
Total Goals
| Over 2.5 | Under 2.5 |
|---|---|
| -144 | +118 |
All odds are correct at the time of publication and are subject to change.
Atletico San Luis vs. Club Leon picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Moneyline | Club Leon | +210 |
| Total Goals | Over 2.5 | -144 |
According to our Liga MX best bets, the top play to make on this game is Club Leon to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Atletico San Luis vs. Club Leon: Correct score and BTTS predictions
Here are the top three most likely final scores according to our model, with a 1-1 draw being the most probable:
| Final Score | Probability |
|---|---|
| ASL 1-1 LEO | 11.3% |
| ASL 2-1 LEO | 8.7% |
| ASL 1-2 LEO | 8.1% |
When it comes to the both teams to score (BTTS) market, we project a 59.8% chance of both sides finding the net and a 40.2% chance that at least one doesn’t.
These predictions are based on each team's average score according to our machine learning model, which means the most likely correct score may differ from our predicted winner.
San Luis vs. Club Leon game-day updates and essential details
Saturday's action between Atletico San Luis and Club Leon at Estadio Alfonso Lastras is scheduled to begin at 9:00 PM ET.
- Who: Atletico San Luis vs. Club Leon
- Date: Saturday, March 21, 2026
- Time: 9:00 PM ET/6:00PM PT
- Venue: Estadio Alfonso Lastras
Conclusion
According to our computer model, Atletico San Luis has a 40.1% win probability on Saturday, Club Leon has a 35.5% win probability, and there is a 24.4% chance that the game will end in a draw.
AI and automation have enhanced this article to quickly deliver accurate Atletico San Luis vs. Club Leon insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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