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San Luis vs. Santos Laguna prediction, odds, Liga MX picks [4/22/2026]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get San Luis vs Santos Laguna predictions for Liga MX Wednesday.
Liga MX action continues on Wednesday at 9:00 PM ET as Santos Laguna squares off with Atletico San Luis in the playoffs at Estadio Alfonso Lastras.
Based on updated simulations, Dimers' advanced Liga MX model projects San Luis as the most likely winner of the Atletico San Luis vs. Santos Laguna game.
This article offers further insights into Wednesday's match, including best bets and picks.
Atletico San Luis vs. Santos Laguna prediction: Who will win?
Using powerful machine learning and statistical analysis, we have simulated the outcome of Wednesday's Liga MX game between Atletico San Luis and Santos Laguna, forming part of our Liga MX predictions coverage.
Our leading predictive model currently indicates a 57.1% chance of Atletico San Luis winning, a 21.3% chance for Santos Laguna, and a 21.6% chance of a draw.
Atletico San Luis vs. Santos Laguna odds
We have researched the best Liga MX odds in America for this game, which are listed here:
| Market | Atletico San Luis | Santos Laguna | Draw |
|---|---|---|---|
| Moneyline | -135 | +330 | +310 |
All odds are correct at the time of publication and are subject to change.
Atletico San Luis vs. Santos Laguna picks and best bet
After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Moneyline | San Luis | -135 |
According to our best Liga MX bets, the top play to make on this game is San Luis to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Atletico San Luis vs. Santos Laguna: Correct score and BTTS predictions
Here are the top three most likely final scores according to our model, with a 1-1 draw being the most probable:
| Final Score | Probability |
|---|---|
| ASL 1-1 SLA | 10% |
| ASL 2-1 SLA | 9.9% |
| ASL 1-0 SLA | 8.8% |
When it comes to the both teams to score (BTTS) market, we project a 58.3% chance of both Atletico San Luis and Santos Laguna finding the net and a 41.7% chance that at least one doesn’t.
These predictions are based on each team's average score according to our machine learning model, which means the most likely correct score may differ from our predicted winner.
San Luis vs. Santos Laguna game-day updates and essential details
Wednesday's matchup between Atletico San Luis and Santos Laguna at Estadio Alfonso Lastras is scheduled to start at 9:00 PM ET.
- Who: Atletico San Luis vs. Santos Laguna
- Date: Wednesday, April 22, 2026
- Time: 9:00 PM ET/6:00PM PT
- Venue: Estadio Alfonso Lastras
Conclusion
According to our computer model, Atletico San Luis has a 57.1% win probability on Wednesday, Santos Laguna has a 21.3% win probability, and there is a 21.6% chance that the game will end in a draw.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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