Indiana vs. Nebraska prediction favors Indiana to win in college football Week 6 [2026]

Using trusted machine learning and data, we have re-simulated the outcome of Indiana vs. Nebraska, forming part of our college football predictions coverage.

Our leading predictive model gives Indiana a 72.8% chance of defeating Nebraska. Our predicted final score has Indiana winning 28-21. According to our model, Nebraska (+9) has a 58.0% chance of covering the spread, while the over/under total of 48.5 points has a 52.1% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Indiana -9 (-115) / Nebraska +9 (-105)
• Moneyline: Indiana -220, Nebraska +290
• Total: Over/Under 48.5 (-108/-112)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Nebraska +9 @ -105 via bet365
• Moneyline: Indiana @ -220 via DraftKings
• Total: Over 48.5 @ -108 via bet365

According to our college football best bets, the top play to make on this game is Nebraska +9 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Nebraska and Indiana at Memorial Stadium is scheduled to begin at 12:00 PM ET.

• Who: Indiana vs. Nebraska
• Date: Saturday, October 10, 2026
• Time: 12:00 PM ET/9:00AM PT
• Venue: Memorial Stadium

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Conclusion

We predict Indiana, with a 72.8% win probability, will likely beat Nebraska in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.