Southern Illinois vs. South Dakota: College Football Week 6 Prediction, Picks & Odds

Southern Illinois vs. South Dakota: Detailed Breakdown

Matchup overview: College Football Week 6

• Teams: Southern Illinois vs. South Dakota
• Date: Saturday, October 10, 2026
• Time: 2:00PM ET
• Venue: The DakotaDome

Current betting odds

• Spread: Southern Illinois (+10.5, -121), South Dakota (-10.5, +102)
• Moneyline: Southern Illinois +275, South Dakota -348
• Total (Over/Under): 57.5 points (-109/-110)

Dimers’ win probabilities

• Southern Illinois: 21.8%
• South Dakota: 78.2%

These probabilities come from two machine learning models that assess more than 100 data points for each college football matchup, combining their outputs to project all our major betting markets.

Projected final score

Our predicted final score for this college football matchup is Southern Illinois 23-34 South Dakota.

This prediction draws on each team's scoring trends and player stats, weighed across both of our data models

Our Prediction: Who Wins?

The numbers give the Southern Illinois a win probability of 21.8%, while the South Dakota have a win probability of 78.2%.

Summary

Southern Illinois faces off against South Dakota in college football action at The DakotaDome on Saturday, October 10, 2026.

Our Southern Illinois vs. South Dakota predictions, built on real-time data and matchup-specific modeling, help guide your decisions. Remember to bet responsibly and within your financial limits.

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For further insights, explore our expert college football predictions and the best college football bets today, while our in-depth analysis includes college football props, college football futures, college football odds, and the latest college football news.