MLB picks today: Wednesday's MLB best bets include Yankees vs. White Sox play [7/29/2026]

Yankees vs. White Sox Over 7.5 runs (+100)

• Edge: 6.1%
• Probability: 56.1%
• Matchup: Yankees vs. White Sox (7:40PM ET)

Our model has identified value on Over 7.5 runs in Yankees vs. White Sox at +100 odds. A 56.1% probability produces an edge of 6.1%, making this the strongest play for today's MLB slate.

Diamondbacks vs. Pirates Over 8.5 runs (+108)

• Edge: 4.7%
• Probability: 52.8%
• Matchup: Diamondbacks vs. Pirates (12:35PM ET)

Diamondbacks vs. Pirates over 8.5 runs carries a 4.7% edge and a probability of 52.8% at +108 odds, according to our model.

Royals vs. Twins Over 8.5 runs (+100)

• Edge: 4.6%
• Probability: 54.6%
• Matchup: Royals vs. Twins (7:40PM ET)

Royals vs. Twins Over 8.5 runs at +100 odds shows a 4.6% edge, supported by a 54.6% probability in simulations.

Giants ML (+115)

• Edge: 4.4%
• Probability: 50.7%
• Matchup: Brewers vs. Giants (3:45PM ET)

A 4.4% edge and 50.7% probability makes Giants at the moneyline a value play in the Brewers vs. Giants matchup, per our model.

Athletics ML (+138)

• Edge: 4.1%
• Probability: 46%
• Matchup: Red Sox vs. Athletics (9:40PM ET)

Athletics ML at +138 odds presents a 4.1% edge, with simulations resulting in a probability of 46%.

Giants +1.5 (-150)

• Edge: 3.8%
• Probability: 63.8%
• Matchup: Brewers vs. Giants (3:45PM ET)

Our model finds value on Giants +1.5 at -150 odds, supported by an edge of 3.8%.

Athletics +1.5 (-113)

• Edge: 3.7%
• Probability: 56.7%
• Matchup: Red Sox vs. Athletics (9:40PM ET)

Our model has uncovered value on Athletics +1.5 at -113 odds. A 56.7% probability produces a 3.7% edge, making this a strong play for today's MLB action.

Orioles vs. Tigers Over 7.5 runs (-104)

• Edge: 3.7%
• Probability: 54.7%
• Matchup: Orioles vs. Tigers (1:10PM ET)

A 3.7% edge on a 54.7% probability makes Over 7.5 runs at -104 odds a solid value play in today's Orioles vs. Tigers matchup.

Reds ML (+120)

• Edge: 3.4%
• Probability: 48.2%
• Matchup: Guardians vs. Reds (7:10PM ET)

Our model projects value on Reds to win at +120 odds. A 48.2% probability produces a 3.4% edge, making Reds the favorable ML play in today's matchup.

Brewers vs. Giants Over 7.5 runs (-104)

• Edge: 3.3%
• Probability: 54.3%
• Matchup: Brewers vs. Giants (3:45PM ET)

Rounding out our top 10 bets, Brewers vs. Giants Over 7.5 runs at -104 odds shows a 54.3% probability and a 3.3% edge.

MLB best bets summary: Wednesday, 7/29/2026

As of 4:00AM ET, here are our top MLB bets by edge recommended by our model:

List of upcoming MLB games to bet on [7/29/2026]

• Phillies vs. Marlins (12:10PM ET, Wednesday)
• D-Backs vs. Pirates (12:35PM ET, Wednesday)
• Blue Jays vs. Nationals (1:05PM ET, Wednesday)
• Orioles vs. Tigers (1:10PM ET, Wednesday)
• Brewers vs. Giants (3:45PM ET, Wednesday)
• Rockies vs. Padres (4:10PM ET, Wednesday)
• Rangers vs. Rays (6:40PM ET, Wednesday)
• Guardians vs. Reds (7:10PM ET, Wednesday)
• Yankees vs. White Sox (7:40PM ET, Wednesday)
• Royals vs. Twins (7:40PM ET, Wednesday)
• Cubs vs. Cardinals (7:45PM ET, Wednesday)
• Astros vs. Angels (9:38PM ET, Wednesday)
• Red Sox vs. Athletics (9:40PM ET, Wednesday)
• Mariners vs. Dodgers (10:10PM ET, Wednesday)

Conclusion

Our MLB best bets are locked and loaded for July 29, 2026, featuring plays such as over 7.5 runs in the Yankees vs. White Sox matchup and over 8.5 runs in the Diamondbacks vs. Pirates matchup. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.