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Read Article NFL best bets today: Week 5 picks include 49ers vs. Seahawks play [10/11/2026]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get NFL best bets and predictions for Sunday, October 11, 2026.
Today’s NFL picks for October 11, 2026 are here, with 49ers vs. Seahawks and Lions vs. Cardinals among the top plays identified by our model across Sunday’s NFL schedule.
Dimers’ predictive analytics engine runs 24/7, going over the latest football odds to uncover legitimate betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.
List of NFL best bets today [10/11, updated 4:03PM ET]
Below, you’ll find today’s NFL best bets, ranked by edge for Sunday, October 11, 2026.
49ers +2.5 (+122)
- Edge: 6.5%
- Probability: 51.5%
- Matchup: 49ers vs. Seahawks (4:25PM ET)
Our model has identified value on 49ers +2.5 at 45¢ odds. A 51.5% probability produces an edge of 6.5%, making this the strongest play for today's NFL slate.
Lions vs. Cardinals Under 54.5 points (+108)
- Edge: 5.4%
- Probability: 53.5%
- Matchup: Lions vs. Cardinals (4:25PM ET)
Lions vs. Cardinals under 54.5 points carries a 5.4% edge and a probability of 53.5% at 48¢ odds, according to our model.
Lions -5.5 (49¢)
- Edge: 3.2%
- Probability: 52.2%
- Matchup: Lions vs. Cardinals (4:25PM ET)
Lions -5.5 vs. Cardinals at 49¢ odds shows a 3.2% edge, supported by a 52.2% probability in simulations.
49ers vs. Seahawks over 46.5 points (-105)
- Edge: 2.3%
- Probability: 53.5%
- Matchup: 49ers vs. Seahawks (4:25PM ET)
A 2.3% edge and 53.5% probability make 49ers vs. Seahawks over 46.5 points a value play in the 49ers vs. Seahawks matchup, per our model.
NFL best bets summary: Sunday, 10/11/2026
As of 4:03PM ET, here are our top NFL bets by edge recommended by our model:
| Matchup | Bet | Odds | Edge | Prob. |
|---|---|---|---|---|
| 49ers vs. Seahawks | 49ers +2.5 | 45¢ @ Polymarket | 6.5% | 51.5% |
| Lions vs. Cardinals | Under 54.5 points | 48¢ @ Novig | 5.4% | 53.5% |
| Lions vs. Cardinals | Lions -5.5 | 49¢ @ Novig | 3.2% | 52.2% |
| 49ers vs. Seahawks | Over 46.5 points | -105 @ DraftKings | 2.3% | 53.5% |
List of upcoming NFL games to bet on [10/11/2026]
- Broncos vs. Chargers (4:05PM ET, Sunday)
- Lions vs. Cardinals (4:25PM ET, Sunday)
- 49ers vs. Seahawks (4:25PM ET, Sunday)
- Ravens vs. Falcons (8:20PM ET, Sunday)
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Conclusion
Our NFL best bets are locked and loaded for October 11, 2026, featuring plays such as 49ers +2.5 vs. Seahawks and under 54.5 points in the Lions vs. Cardinals matchup. Powered by advanced simulations, these picks are here to boost your betting game.
Our predictions are sourced from current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.
All odds and probabilities in this article are correct and accurate at the time of publication.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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