Lions vs. Bills: NFL Week 2 Prediction, Picks & Odds
Spread
- Lions
- Bills
Lions vs. Bills: Detailed Breakdown
Matchup overview: NFL Week 2
- Teams: Detroit Lions vs. Buffalo Bills
- Date: Thursday, September 17, 2026
- Time: 8:15PM ET
- Venue: Highmark Stadium
Current betting odds
- Spread: Lions (+3.5, -111), Bills (-3.5, -107)
- Moneyline: Lions +160, Bills -162
- Total (Over/Under): 52.5 points (-109/-112)
Dimers’ win probabilities
- Lions: 38.4%
- Bills: 61.6%
These probabilities come from two machine learning models that assess more than 100 data points for each NFL matchup, combining their outputs to project all our major betting markets.
Projected final score
Our predicted final score for this NFL matchup is Lions 23-27 Bills.
This prediction draws on each team's scoring trends and player stats, weighed across both of our data models.
Our Prediction: Who Wins?
The numbers give the Lions a win probability of 38.4%, while the Bills have a win probability of 61.6%.
Summary
The Lions face off against the Bills in the NFL at Highmark Stadium on Thursday, September 17, 2026.
Our Lions vs. Bills predictions, built on real-time data and matchup-specific modeling, help guide your decisions.. Remember to bet responsibly and within your financial limits.
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