Colts vs. Chiefs: NFL Week 2 Prediction, Picks & Odds
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- Colts
- Chiefs
Colts vs. Chiefs: Detailed Breakdown
Matchup overview: NFL Week 2
- Teams: Indianapolis Colts vs. Kansas City Chiefs
- Date: Sunday, September 20, 2026
- Time: 8:20PM ET
- Venue: Arrowhead Stadium
Current betting odds
- Spread: Colts (+6.5, -109), Chiefs (-6.5, -109)
- Moneyline: Colts +250, Chiefs -257
- Total (Over/Under): 47.5 points (-106/-110)
Dimers’ win probabilities
- Colts: 29.9%
- Chiefs: 70.1%
These probabilities come from two machine learning models that assess more than 100 data points for each NFL matchup, combining their outputs to project all our major betting markets.
Projected final score
Our predicted final score for this NFL matchup is Colts 20-26 Chiefs.
This prediction draws on each team's scoring trends and player stats, weighed across both of our data models.
Our Prediction: Who Wins?
The numbers give the Colts a win probability of 29.9%, while the Chiefs have a win probability of 70.1%.
Summary
The Colts face off against the Chiefs in the NFL at Arrowhead Stadium on Sunday, September 20, 2026.
Our Colts vs. Chiefs predictions, built on real-time data and matchup-specific modeling, help guide your decisions.. Remember to bet responsibly and within your financial limits.
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For further insights, explore our expert NFL predictions and the best NFL bets today, while our in-depth analysis includes NFL props, NFL futures, NFL odds, and the latest NFL news.