Cardinals vs. 49ers: NFL Week 3 Prediction, Picks & Odds
Spread
- Cardinals
- 49ers
Cardinals vs. 49ers: Detailed Breakdown
Matchup overview: NFL Week 3
- Teams: Arizona Cardinals vs. San Francisco 49ers
- Date: Sunday, September 27, 2026
- Time: 4:05PM ET
- Venue: Levi's Stadium
Current betting odds
- Spread: Cardinals (+11.5, -110), 49ers (-11.5, -110)
- Moneyline: Cardinals +470, 49ers -600
- Total (Over/Under): 47.5 points (-115/-115)
Dimers’ win probabilities
- Cardinals: 16.4%
- 49ers: 83.6%
These probabilities come from two machine learning models that assess more than 100 data points for each NFL matchup, combining their outputs to project all our major betting markets.
Projected final score
Our predicted final score for this NFL matchup is Cardinals 17-28 49ers.
This prediction draws on each team's scoring trends and player stats, weighed across both of our data models.
Our Prediction: Who Wins?
The numbers give the Cardinals a win probability of 16.4%, while the 49ers have a win probability of 83.6%.
Summary
The Cardinals face off against the 49ers in the NFL at Levi's Stadium on Sunday, September 27, 2026.
Our Cardinals vs. 49ers predictions, built on real-time data and matchup-specific modeling, help guide your decisions.. Remember to bet responsibly and within your financial limits.
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