Lions vs. Cardinals: NFL Week 5 Prediction, Picks & Odds
Spread
- Lions
- Cardinals
Lions vs. Cardinals: Detailed Breakdown
Matchup overview: NFL Week 5
- Teams: Detroit Lions vs. Arizona Cardinals
- Date: Sunday, October 11, 2026
- Time: 4:25PM ET
- Venue: State Farm Stadium
Current betting odds
- Spread: Lions (-8, -115), Cardinals (+8, -115)
- Moneyline: Lions -395, Cardinals +310
- Total (Over/Under): 48.5 points (-110/-110)
Dimers’ win probabilities
- Lions: 76.0%
- Cardinals: 24.0%
These probabilities come from two machine learning models that assess more than 100 data points for each NFL matchup, combining their outputs to project all our major betting markets.
Projected final score
Our predicted final score for this NFL matchup is Lions 28-19 Cardinals.
This prediction draws on each team's scoring trends and player stats, weighed across both of our data models.
Our Prediction: Who Wins?
The numbers give the Lions a win probability of 76.0%, while the Cardinals have a win probability of 24.0%.
Summary
The Lions face off against the Cardinals in the NFL at State Farm Stadium on Sunday, October 11, 2026.
Our Lions vs. Cardinals predictions, built on real-time data and matchup-specific modeling, help guide your decisions.. Remember to bet responsibly and within your financial limits.
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