Marcos Giron vs. Ignacio Buse prediction, odds, picks for US Open 2026

Marcos Giron will square off with Ignacio Buse in the first round of the US Open Men's Singles 2026 on Wednesday.

Dimers' advanced tennis model projects Ignacio Buse as the most likely winner in this Giron vs. Buse prediction.

This article offers an expanded analysis of Wednesday's match, including best bets and picks.

Giron vs. Buse prediction and odds

Using powerful machine learning and data, we have simulated the outcome of Wednesday's Giron-Buse men's singles match, forming part of our tennis predictions coverage.

Our leading predictive model currently gives Buse a 56% chance of beating Giron in the US Open 2026.

Latest betting odds

We have researched the most up-to-date betting odds in America for this match, which are listed here:

• Moneyline: Ignacio Buse -170, Marcos Giron +140

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Giron @ +140 via DraftKings
• First Set: Buse @ -130 via DraftKings

According to our tennis best bets, the top play to make on this match is Marcos Giron to win.

Although Giron is less than likely to win, he provides the best value at the current available odds.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & first serve details

The US Open 2026 match between Marcos Giron and Ignacio Buse is scheduled to start on Wednesday at 12:30 PM ET.

• Who: Marcos Giron vs. Ignacio Buse
• Date: Wednesday, September 2, 2026
• Approx. Time: 12:30 PM ET/9:30AM PT
• Tournament: US Open Men's Singles 2026
• Round: First round

All dates and times in this article are United States Eastern Time unless otherwise noted.

Conclusion

We predict Ignacio Buse, with a 56% win probability, will likely beat Marcos Giron at the US Open 2026.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.