Moise Kouame vs. Lorenzo Musetti prediction, odds, picks for ATP Lyon Open 2026

Moise Kouame and Lorenzo Musetti will lock horns in the round of 16 of the ATP Lyon Open event on Wednesday.

Dimers' advanced tennis model projects Lorenzo Musetti as the most likely winner in this Kouame vs. Musetti prediction.

This article offers further insights into Wednesday's match, including best bets and picks.

Kouame vs. Musetti prediction and odds

Using trusted machine learning and data, we have re-simulated the outcome of Wednesday's Kouame-Musetti men's singles match, forming part of our tennis predictions coverage.

Our leading predictive model currently gives Musetti a 72% chance of winning against Kouame at the ATP Lyon Open tournament. Additionally, Musetti has a 67% chance of winning the first set. The simulations also show Kouame (+4.5) has a 53% chance of covering the games spread, while the **over/under of 21.5 games has an equal 50-50 chance of hitting, according to our model.

Latest betting odds

We have researched the most up-to-date betting odds in America for this match, which are listed here:

• Moneyline: Lorenzo Musetti -333, Moise Kouame +295
• First Set: Kouame +220, Musetti -278

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Kouame @ +295 via DraftKings
• First Set: Musetti @ -110 via DraftKings

According to our best tennis bets, the top play to make on this match is over 21.5 total games.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & first serve details

The ATP Lyon Open match between Moise Kouame and Lorenzo Musetti is scheduled to start on Wednesday at 1:00 PM ET.

• Who: Moise Kouame vs. Lorenzo Musetti
• Date: Wednesday, October 21, 2026
• Approx. Time: 1:00 PM ET/10:00 AM PT
• Tournament: ATP Lyon, France Men's Singles 2026
• Round: Round of 16

All dates and times in this article are United States Eastern Time unless otherwise noted.

Conclusion

We predict Lorenzo Musetti, with a 72% win probability, will likely beat Moise Kouame at the ATP Lyon Open tournament.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary Tennis prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.