SIU-Edwardsville vs. Duke prediction, odds, pick for Nov. 13, 2026

Duke is favored to beat SIU-Edwardsville at Cameron Indoor Stadium on Friday (8:00 PM ET), according to Dimers' men's college basketball model.

Our SIU-Edwardsville vs. Duke prediction gives SIU-Edwardsville a 99.5% chance of winning, but the latest odds suggest there's betting value on SIU-Edwardsville to cover at +42.5.

SIU-Edwardsville vs. Duke key predictions

• Predicted score: Duke 91-57 SIU-Edwardsville
• Duke win probability: 99.5%
• SIU-Edwardsville win probability: 0.5%
• SIU-Edwardsville +42.5 spread: 59.0% cover probability
• Over 147.5 points: 51.9% probability

Our men's college basketball predictions project each team's final score using offensive and defensive efficiency, recent performance, long-term trends, and matchup-specific factors.

We calculate win, spread, and total probabilities based on these projections and historical CBB scoring patterns, then compare them with the latest odds to find betting value.

SIU-Edwardsville vs. Duke odds

Below are the best available odds across the moneyline, spread, and total points markets.

• SIU-Edwardsville moneyline: +8000 (FanDuel)
• Duke moneyline: -100000 (FanDuel)
• SIU-Edwardsville +42.5: -105 (BetRivers)
• Duke -42.5: -110 (FanDuel)
• Over 147.5 points: -108 (BetRivers)
• Under 147.5 points: -114 (BetRivers)

Odds are subject to change and may vary by location.

SIU-Edwardsville vs. Duke pick: SIU-Edwardsville +42.5 (-105)

Our model makes Duke the likelier winner, but our best value bet is the Blue Devils to cover the +42.5 spread at -105 on BetRivers.

Those odds give SIU-Edwardsville an implied cover probability of 51.2%, while our model puts it at 59.0%.

That's a 7.8% edge, the largest across the moneyline, spread, and total points markets.

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• Best bets across the moneyline, spread, and total points markets
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SIU-Edwardsville vs. Duke game details

• Matchup: SIU-Edwardsville vs. Duke Blue Devils
• Date: Friday, November 13, 2026
• Time: 8:00 PM ET
• Venue: Cameron Indoor Stadium

About this prediction

This preview uses predictions from our men's college basketball models, presented through a template written by our editorial team. Matchup details fill in automatically.

Predictions are estimates, not guarantees, and can change as new information comes in, such as injury news or lineup changes. Learn how our predictions work.

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