Southern Miss vs. Iowa State prediction, odds, pick for Nov. 6, 2026

Iowa State is favored to beat Southern Miss at James H. Hilton Coliseum on Friday (8:00 PM ET), according to Dimers' men's college basketball model.

Our Southern Miss vs. Iowa State prediction gives Southern Miss a 98.6% chance of winning, but the latest odds suggest there's betting value on Southern Miss to cover at +31.5.

Southern Miss vs. Iowa State key predictions

• Predicted score: Iowa State 88-61 Southern Miss
• Iowa State win probability: 98.6%
• Southern Miss win probability: 1.4%
• Southern Miss +31.5 spread: 56.0% cover probability
• Over 149.5 points: 50.0% probability

Our men's college basketball predictions project each team's final score using offensive and defensive efficiency, recent performance, long-term trends, and matchup-specific factors.

We calculate win, spread, and total probabilities based on these projections and historical CBB scoring patterns, then compare them with the latest odds to find betting value.

Southern Miss vs. Iowa State odds

Here are the best available odds across the moneyline, spread, and total points markets we track.

• Southern Miss moneyline: +8000 (FanDuel)
• Iowa State moneyline: -10000 (BetMGM)
• Southern Miss +31.5: -115 (BetMGM)
• Iowa State -31.5: -102 (DraftKings)
• Over 149.5 points: -115 (DraftKings)
• Under 149.5 points: -105 (DraftKings)

Odds are subject to change and may vary by location.

Southern Miss vs. Iowa State pick: Southern Miss +31.5 (-115)

Our model makes Iowa State the likelier winner, but our best value bet is the Cyclones to cover the +31.5 spread at -115 on BetMGM.

Those odds give Southern Miss an implied cover probability of 53.5%, while our model puts it at 56.0%.

That's a 2.5% edge, the largest across the moneyline, spread, and total points markets for this game.

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Southern Miss vs. Iowa State game details

• Matchup: Southern Miss vs. Iowa State Cyclones
• Date: Friday, November 6, 2026
• Time: 8:00 PM ET
• Venue: James H. Hilton Coliseum

About this prediction

This preview uses predictions from our men's college basketball models, presented through a template written by our editorial team. Matchup details fill in automatically.

Predictions are estimates, not guarantees, and can change as new information comes in, such as injury news or lineup changes. Learn how our predictions work.

Dimers encourages responsible gambling.