Southern Miss vs. Iowa State Prediction, Picks & Odds
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Southern Miss vs. Iowa State prediction & analysis
Game overview: Men's college basketball Friday
- Teams: Southern Miss vs. Iowa State
- Date: Friday, November 6, 2026
- Tip-off: 8:00PM ET
- Venue: James H. Hilton Coliseum
Current betting odds
- Spread: Southern Miss (+30.5, -109), Iowa State (-30.5, -110)
- Total (Over/Under): 145.5 points (-105/-110)
- Moneyline: Southern Miss +8000, Iowa State -10000
Dimers’ win probabilities
- Southern Miss: 1.3%
- Iowa State: 98.7%
Our college basketball win probabilities come from a machine learning model that assesses each team's offensive and defensive performance, along with factors such as recent form, player availability, home-court advantage, and matchup dynamics.
The model uses these projections to forecast probabilities for the moneyline, spread, total points, and final score.
Projected Final Score
Our model projects the final score for this college basketball matchup as Southern Miss 59 and Iowa State 86.
This is a margin of 27 points against a spread of 30.5, and a projected total of 145 points against a market line of 145.5.
A projected score is the middle of a range, not a forecast of the exact result. Use it to see how the game is likely to play out and how each side projects against the spread.
Our Prediction: Who Wins?
After extensive simulations, our model gives Southern Miss a win probability of 1.3%, while Iowa State has a win probability of 98.7%.
Summary
According to our analysis, Iowa State is more likely to beat Southern Miss in the men's college basketball game at James H. Hilton Coliseum on Friday.
Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.
Our Southern Miss vs. Iowa State predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.
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For further insights, explore our expert men's college basketball predictions and the best men's college basketball bets today, while our in-depth analysis includes men's college basketball props, men's college basketball futures, men's college basketball odds, and the latest men's college basketball news.

