Illinois vs. Ohio State prediction favors Ohio State to win in college football Week 4 [2026]

Ohio State and Illinois will meet in Week 4 college football action at Ohio Stadium on Saturday, starting at 12:00 PM ET.

Dimers' advanced college football model projects Ohio State as the most likely winner in this Illinois vs. Ohio State prediction.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Illinois vs. Ohio State prediction and odds

Using innovative machine learning and data analysis, we have re-simulated the outcome of Illinois vs. Ohio State, forming part of our college football predictions coverage.

Our leading predictive model currently gives Ohio State a 96.9% chance of beating Illinois. Our predicted final score has Ohio State winning 39-14. According to our model, Illinois (+26.5) has a 53.2% chance of covering the spread, while the over/under total of 53.5 points has a 51.4% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Illinois +26.5 (-110) / Ohio State -26.5 (-109)
• Moneyline: Illinois +1650, Ohio State -4000
• Total: Over/Under 53.5 (-105/-106)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Illinois +26.5 @ -110 via BetRivers
• Moneyline: Ohio State @ -4000 via DraftKings
• Total: Over 53.5 @ -105 via bet365

According to our best college football bets, the top play to make on this game is Illinois +26.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Ohio State and Illinois at Ohio Stadium is scheduled to commence at 12:00 PM ET.

• Who: Illinois vs. Ohio State
• Date: Saturday, September 26, 2026
• Time: 12:00 PM ET/9:00AM PT
• Venue: Ohio Stadium

College football Week 4 promos

Make the most of Dimers' Illinois vs. Ohio State predictions by exploring the Bet365 Sportsbook offer below:

Conclusion

We predict Ohio State, with a 96.9% win probability, will likely beat Illinois in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.