Lehigh vs. Pennsylvania prediction: Why Lehigh is favored to win in college football Week 4 [2026]

Pennsylvania will take on the favored Lehigh in Week 4 college football action at Franklin Field on Saturday, beginning at 1:00 PM ET.

Dimers' proven college football model projects Lehigh as the most likely winner in this Lehigh vs. Pennsylvania prediction.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Lehigh vs. Pennsylvania prediction and odds

Using trusted machine learning and data analysis, we have re-simulated the outcome of Lehigh vs. Pennsylvania, forming part of our college football predictions coverage.

Our famous predictive model currently gives Lehigh a 78.5% chance of defeating Pennsylvania. Our predicted final score has Lehigh winning 28-17. According to our model, Pennsylvania (+12.5) has a 53.3% chance of covering the spread, while the 43.5-point over/under has a 55.8% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Lehigh -12.5 (-110) / Pennsylvania +12.5 (-120)
• Moneyline: Lehigh -450, Pennsylvania +340
• Total: Over/Under 43.5 (-120/+100)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Pennsylvania +12.5 @ -120 via bet365
• Moneyline: Pennsylvania @ +340 via Caesars
• Total: Over 43.5 @ -120 via bet365

According to our college football best bets, the top play to make on this game is Over 43.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Pennsylvania and Lehigh at Franklin Field is scheduled to begin at 1:00 PM ET.

• Who: Lehigh vs. Pennsylvania
• Date: Saturday, September 26, 2026
• Time: 1:00 PM ET/10:00AM PT
• Venue: Franklin Field

College football Week 4 promos

Make the most of Dimers' Lehigh vs. Pennsylvania predictions by exploring the Bet365 Sportsbook offer below:

Conclusion

We predict Lehigh, with a 78.5% win probability, will likely beat Pennsylvania in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.