Missouri vs. Ole Miss prediction: Why Mississippi is favored to win in college football Week 7 [2026]

Mississippi will square off with Missouri in Week 7 college football action at Vaught-Hemingway Stadium on Saturday, beginning at 3:30 PM ET.

Dimers' advanced college football model projects Mississippi as the most likely winner in this Missouri vs. Ole Miss prediction.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Missouri vs. Ole Miss prediction and odds

Using innovative machine learning and data, we have re-simulated the result of Missouri vs. Ole Miss, forming part of our college football predictions coverage.

Our leading predictive model currently gives Mississippi a 63.9% chance of beating Missouri. Our predicted final score has Mississippi winning 30-26. According to our model, Missouri (+6.5) has a 54.4% chance of covering the spread, while the 58.5-point over/under has a 52.5% chance of staying under.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Missouri +6.5 (-135) / Ole Miss -6.5 (+130)
• Moneyline: Missouri +167, Ole Miss -170
• Total: Over/Under 58.5 (+113/-115)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Mississippi -6.5 @ 44¢ via Novig
• Moneyline: Mississippi @ 63¢ via Novig
• Total: Over 58.5 @ 47¢ via Novig

According to our college football best bets, the top play to make on this game is Mississippi -6.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Ole Miss and Missouri at Vaught-Hemingway Stadium is scheduled to begin at 3:30 PM ET.

• Who: Missouri vs. Mississippi
• Date: Saturday, October 17, 2026
• Time: 3:30 PM ET/12:30PM PT
• Venue: Vaught-Hemingway Stadium

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Conclusion

We predict Mississippi, with a 63.9% win probability, will likely beat Missouri in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.