Ohio State vs. Indiana prediction: Why Ohio State is favored to win in college football Week 7 [2026]

Indiana and Ohio State will lock horns in Week 7 college football action at Memorial Stadium on Saturday, beginning at 12:00 PM ET.

Dimers' proven college football model projects Ohio State as the most likely winner in this Ohio State vs. Indiana prediction.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Ohio State vs. Indiana prediction and odds

Using innovative machine learning and data, we have re-simulated the outcome of Ohio State vs. Indiana, forming part of our college football predictions coverage.

Our famous predictive model gives Ohio State a 57.5% chance of beating Indiana. Our predicted final score has Ohio State winning 26-23. According to our model, Ohio State (-2.5) has a 53.6% chance of covering the spread, while the 49-point over/under has a 53.3% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Ohio State -2.5 (-118) / Indiana +2.5 (+100)
• Moneyline: Ohio State -139, Indiana +128
• Total: Over/Under 49 (-105/-109)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Ohio State -2.5 @ -118 via bet365
• Moneyline: Ohio State @ -139 via bet365
• Total: Over 49 @ -105 via Caesars

According to our best college football bets, the top play to make on this game is Over 49 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Indiana and Ohio State at Memorial Stadium is scheduled to start at 12:00 PM ET.

• Who: Ohio State vs. Indiana
• Date: Saturday, October 17, 2026
• Time: 12:00 PM ET/9:00AM PT
• Venue: Memorial Stadium

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Conclusion

We predict Ohio State, with a 57.5% win probability, will likely beat Indiana in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.