San Diego vs. Butler prediction favors San Diego to win in college football Week 6 [2026]

Butler will face San Diego in Week 6 college football action at Bud and Jackie Sellick Bowl on Saturday, beginning at 1:00 PM ET.

Dimers' proven college football model projects San Diego as the most likely winner in this San Diego vs. Butler prediction.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

San Diego vs. Butler prediction and odds

Using innovative machine learning and data, we have re-simulated the result of San Diego vs. Butler, forming part of our college football predictions coverage.

Our famous predictive model currently gives San Diego a 58.0% chance of defeating Butler. Our predicted final score has San Diego winning 31-28. According to our model, Butler (+3) has a 51.4% chance of covering the spread, while the over/under total of 60.5 points has a 51.8% chance of staying under.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: San Diego -3 (-107) / Butler +3 (-110)
• Moneyline: San Diego -154, Butler +130
• Total: Over/Under 60.5 (-110/-110)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Butler +3 @ -110 via bet365
• Moneyline: Butler @ +130 via bet365
• Total: Under 60.5 @ -110 via Caesars

According to our college football best bets, the top play to make on this game is Under 60.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between Butler and San Diego at Bud and Jackie Sellick Bowl is scheduled to begin at 1:00 PM ET.

• Who: San Diego vs. Butler
• Date: Saturday, October 10, 2026
• Time: 1:00 PM ET/10:00AM PT
• Venue: Bud and Jackie Sellick Bowl

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Conclusion

We predict San Diego, with a 58.0% win probability, will likely beat Butler in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.