South Carolina State vs. Charleston Southern prediction: Why South Carolina State is favored to win in college football Week 6 [2026]

Charleston Southern and South Carolina State will clash in Week 6 college football action at Buccaneer Field on Saturday, commencing at 1:00 PM ET.

Dimers' proven college football model projects South Carolina State as the most likely winner in this South Carolina State vs. Charleston Southern prediction.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

South Carolina State vs. Charleston Southern prediction and odds

Using innovative machine learning and data, we have re-simulated the result of South Carolina State vs. Charleston Southern, forming part of our college football predictions coverage.

Our famous predictive model currently gives South Carolina State a 68.8% chance of defeating Charleston Southern. Our predicted final score has South Carolina State winning 22-17. According to our model, Charleston Southern (+6.5) has a 51.8% chance of covering the spread, while the over/under total of 37.5 points has a 56.3% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: South Carolina State -6.5 (-105) / Charleston Southern +6.5 (-103)
• Moneyline: South Carolina State -250, Charleston Southern +216
• Total: Over/Under 37.5 (-110/-110)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Charleston Southern +6.5 @ -103 via DraftKings
• Moneyline: Charleston Southern @ +216 via DraftKings
• Total: Over 37.5 @ -110 via bet365

According to our college football best bets, the top play to make on this game is Over 37.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between Charleston Southern and South Carolina State at Buccaneer Field is scheduled to start at 1:00 PM ET.

• Who: South Carolina State vs. Charleston Southern
• Date: Saturday, October 10, 2026
• Time: 1:00 PM ET/10:00AM PT
• Venue: Buccaneer Field

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Conclusion

We predict South Carolina State, with a 68.8% win probability, will likely beat Charleston Southern in Saturday's college football matchup.

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This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.