Cruz Azul vs. Santos Laguna prediction, odds, Liga MX picks [9/6/2026]

Using trusted machine learning and data, we have simulated the outcome of Sunday's Liga MX game between Cruz Azul and Santos Laguna, forming part of our Liga MX predictions coverage.

Our independent predictive model currently suggests a 72.8% chance of Cruz Azul winning, a 10.9% chance for Santos Laguna, and a 16.2% chance of a draw.

Additionally, the over/under total of 2.5 goals has a 64.6% chance of going over, with a 52.5% likelihood that both teams score.

Latest betting odds

We have sourced the best Liga MX odds in America for this game, which are listed here:

• Moneyline: Santos Laguna +600, Cruz Azul -255
• Total Goals: Over/Under 2.5 (-245/+194)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Cruz Azul @ -255 via DraftKings
• Total Goals: Under 2.5 @ +194 via FanDuel

According to our Liga MX best bets, the top play to make on this game is Under 2.5 total goals.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Correct score and BTTS projections

Here are the top three most likely final scores according to our model, with a 2-0 Cruz Azul win being the most probable:

• Cruz Azul 2-0 Santos Laguna (11% probability)
• Cruz Azul 2-1 Santos Laguna (9.4%)
• Cruz Azul 3-0 Santos Laguna (9.1%)

When it comes to the both teams to score (BTTS) market, we project a 52.5% chance of both sides finding the net and a 47.5% chance that at least one doesn’t.

Game info & kickoff details

Sunday's Liga MX matchup between Cruz Azul and Santos Laguna at Estadio Banorte is scheduled to commence at 7:00 PM ET.

• Who: Cruz Azul vs. Santos Laguna
• Date: Sunday, September 6, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: Estadio Banorte

Conclusion

According to our computer model, Cruz Azul has a 72.8% win probability on Sunday, Santos Laguna has a 10.9% win probability, and there is a 16.2% chance that the game will end in a draw.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.