Santos Laguna vs. Pachuca prediction, odds, Liga MX picks [9/26/2026]

Using innovative machine learning and data analysis, we have re-simulated the result of Saturday's Liga MX matchup between Santos Laguna and Pachuca, forming part of our Liga MX predictions coverage.

Our leading predictive model currently indicates a 28.2% chance of Santos Laguna winning, a 47.9% chance for Pachuca, and a 24.0% chance of a draw. Additionally, the 2.5-goal over/under has a 56.2% chance of going over., with a 58.0% chance that both teams score.

Latest betting odds

We have sourced the best Liga MX odds in America for this game, which are listed here:

• Moneyline: Pachuca +110, Santos Laguna +210
• Total Goals: Over/Under 2.5 (-170/+138)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Pachuca @ +110 via DraftKings
• Total Goals: Under 2.5 @ +138 via FanDuel

According to our best Liga MX bets, the top play to make on this game is Under 2.5 total goals.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Correct score and BTTS projections

Here are the top three most likely final scores according to our model, with a 1-1 draw being the most probable:

• Santos Laguna 1-1 Pachuca (11.2% probability)
• Santos Laguna 1-2 Pachuca (9.5%)
• Santos Laguna 0-1 Pachuca (9%)

When it comes to the both teams to score (BTTS) market, we project a 58.0% chance of both sides finding the net and a 42.0% chance that at least one doesn’t.

These predictions are based on each team's average score according to our machine learning model, meaning the most likely correct score can differ from our predicted winner.

Game info & kickoff details

Saturday's Liga MX game between Santos Laguna and Pachuca at Estadio Corona is scheduled to begin at 11:05 PM ET.

• Who: Santos Laguna vs. Pachuca
• Date: Saturday, September 26, 2026
• Time: 11:05 PM ET/8:05PM PT
• Venue: Estadio Corona

Conclusion

According to our computer model, Santos Laguna has a 28.2% win probability on Saturday, Pachuca has a 47.9% win probability, and there is a 24.0% chance that the game will end in a draw.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary Liga MX prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.