Lloyd Harris vs. Stefanos Tsitsipas prediction, odds, picks for US Open 2026

Using powerful machine learning and data analysis, we have simulated the outcome of Wednesday's Harris-Tsitsipas men's singles match, forming part of our tennis predictions coverage.

Our leading predictive model currently gives Tsitsipas a 68% chance of defeating Harris in the US Open 2026.

Latest betting odds

We have researched the most up-to-date betting odds in America for this match, which are listed here:

• Moneyline: Stefanos Tsitsipas -250, Lloyd Harris +210

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Harris @ +210 via DraftKings
• First Set: Tsitsipas @ -105 via DraftKings

According to our tennis best bets, the top play to make on this match is Lloyd Harris to win the first set.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & first serve details

The US Open 2026 match between Lloyd Harris and Stefanos Tsitsipas is scheduled to start on Wednesday at 5:10 PM ET.

• Who: Lloyd Harris vs. Stefanos Tsitsipas
• Date: Wednesday, September 2, 2026
• Approx. Time: 5:10 PM ET/2:10PM PT
• Tournament: US Open Men's Singles 2026
• Round: Second round

All dates and times in this article are United States Eastern Time unless otherwise noted.

Conclusion

We predict Stefanos Tsitsipas, with a 68% win probability, will likely beat Lloyd Harris at the US Open 2026.

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