Buffalo vs. Miami Ohio prediction: Why Miami Ohio is favored to win Week 10 MACtion clash

Using trusted machine learning and data analysis, we have re-simulated the outcome of Buffalo vs. Miami Ohio, forming part of our college football predictions coverage.

Our independent predictive model gives Miami Ohio a 72.3% chance of beating Buffalo. Our predicted final score has Miami Ohio winning 27-19. According to our model, Miami Ohio (-6.5) has a 54.0% chance of covering the spread, while the over/under total of 46.5 points has a 50.9% chance of staying under.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Buffalo +6.5 (+100) / Miami Ohio -6.5 (-104)
• Moneyline: Buffalo +212, Miami Ohio -217
• Total: Over/Under 46.5 (+117/-130)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Miami Ohio -6.5 @ 51¢ via Novig
• Moneyline: Miami Ohio @ 69¢ via Novig
• Total: Over 46.5 @ 46¢ via Novig

According to our college football best bets, the top play to make on this game is Miami Ohio to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Tuesday's college football action between Miami Ohio and Buffalo at Fred C. Yager Stadium is scheduled to start at 8:00 PM ET.

• Who: Buffalo vs. Miami Ohio
• Date: Tuesday, November 3, 2026
• Time: 8:00 PM ET/5:00 PM PT
• Venue: Fred C. Yager Stadium

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Conclusion

We predict Miami Ohio, with a 72.3% win probability, will likely beat Buffalo in Tuesday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.