Columbia vs. Pennsylvania prediction: Why Pennsylvania is favored to win in college football Week 7 [2026]

Using innovative machine learning and statistical analysis, we have re-simulated the result of Columbia vs. Pennsylvania, forming part of our college football predictions coverage.

Our independent predictive model currently gives Pennsylvania a 70.3% chance of defeating Columbia. Our predicted final score has Pennsylvania winning 27-19. According to our model, Pennsylvania (-6.5) has a 52.5% chance of covering the spread, while the 46.5-point over/under has a 52.4% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Columbia +6.5 (-116) / Pennsylvania -6.5 (-107)
• Moneyline: Columbia +187, Pennsylvania -235
• Total: Over/Under 46.5 (-112/-110)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Pennsylvania -6.5 @ -107 via DraftKings
• Moneyline: Pennsylvania @ -235 via bet365
• Total: Over 46.5 @ -112 via DraftKings

According to our best college football bets, the top play to make on this game is Pennsylvania -6.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Friday's college football matchup between Pennsylvania and Columbia at Franklin Field is scheduled to start at 7:00 PM ET.

• Who: Columbia vs. Pennsylvania
• Date: Friday, October 16, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: Franklin Field

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Conclusion

We predict Pennsylvania, with a 70.3% win probability, will likely beat Columbia in Friday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.