East Carolina vs. Old Dominion prediction favors Old Dominion to win in college football Week 3 [2026]

Using powerful machine learning and data analysis, we have re-simulated the outcome of East Carolina vs. Old Dominion, forming part of our college football predictions coverage.

Our leading predictive model currently gives Old Dominion a 62.6% chance of defeating East Carolina. Our predicted final score has Old Dominion winning 27-22. According to our model, Old Dominion (-3) has a 55.5% chance of covering the spread, while the 48.5-point over/under has a 53.8% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: East Carolina +3 (-115) / Old Dominion -3 (-104)
• Moneyline: East Carolina +125, Old Dominion -142
• Total: Over/Under 48.5 (-115/-102)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Old Dominion -3 @ -104 via Caesars
• Moneyline: Old Dominion @ -142 via FanDuel
• Total: Over 48.5 @ -115 via bet365

According to our college football best bets, the top play to make on this game is Old Dominion -3 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Old Dominion and East Carolina at Kornblau Field at S.B. Ballard Stadium is scheduled to commence at 6:00 PM ET.

• Who: East Carolina vs. Old Dominion
• Date: Saturday, September 19, 2026
• Time: 6:00 PM ET/3:00PM PT
• Venue: Kornblau Field at S.B. Ballard Stadium

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Conclusion

We predict Old Dominion, with a 62.6% win probability, will likely beat East Carolina in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.