Florida International vs. USF prediction: South Florida favored to win in college football Week 1 [2026]

South Florida and Florida International will clash in Week 1 college football action at Raymond James Stadium on Saturday, with kickoff at 7:00 PM ET.

Dimers' advanced college football model projects South Florida as the most likely winner in this Florida International vs. USF prediction.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, backed by the same system that has dominated college football and NFL betting markets across multiple seasons.

Florida International vs. USF prediction and odds

Using powerful machine learning and data, we have simulated the outcome of Florida International vs. USF, forming part of our college football predictions coverage.

Our leading predictive model currently gives South Florida a 76.2% chance of beating Florida International. Our predicted final score has South Florida winning 33-22.

According to our model, Florida International (+14.5) has a 56.2% chance of covering the spread, while the over/under total of 53 points has a 57.4% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Florida International +14.5 (-105) / USF -14.5 (-105)
• Moneyline: Florida International +500, USF -550
• Total: Over/Under 53 (-108/-110)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Florida International +14.5 @ -105 via ESPN BET
• Moneyline: Florida International @ +500 via ESPN BET
• Total: Over 53 @ -108 via Caesars

According to our best college football bets, the top play to make on this game is Florida International to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between USF and Florida International at Raymond James Stadium is scheduled to begin at 7:00 PM ET.

• Who: Florida International vs. South Florida
• Date: Saturday, September 5, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: Raymond James Stadium

College football Week 1 promos

Make the most of Dimers' Florida International vs. South Florida predictions by exploring the Underdog Fantasy offfer below

Conclusion

We predict South Florida, with a 76.2% win probability, will likely beat Florida International in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.