Holy Cross vs. Miami Ohio prediction: Why Miami Ohio is favored to win in college football Week 2 [2026]

Miami Ohio and Holy Cross will clash in Week 2 college football action at Fred C. Yager Stadium on Saturday, starting at 1:00 PM ET.

Dimers' advanced college football model projects Miami Ohio as the most likely winner in this Holy Cross vs. Miami Ohio prediction.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, backed by the same system that has dominated college football and NFL betting markets across multiple seasons.

Holy Cross vs. Miami Ohio prediction and odds

Using trusted machine learning and data, we have re-simulated the outcome of Holy Cross vs. Miami Ohio, forming part of our college football predictions coverage.

Our leading predictive model currently gives Miami Ohio a 97.9% chance of defeating Holy Cross. Our predicted final score has Miami Ohio winning 38-9. According to our model, Holy Cross (+30.5) has a 53.6% chance of covering the spread, while the 47.5-point over/under has a 53.5% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Holy Cross +30.5 (-108) / Miami Ohio -30.5 (-110)
• Moneyline: Holy Cross +2500, Miami Ohio -6502
• Total: Over/Under 47.5 (-105/-110)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Holy Cross +30.5 @ -108 via BetRivers
• Moneyline: Miami Ohio @ -6502 via DraftKings
• Total: Over 47.5 @ -105 via DraftKings

According to our college football best bets, the top play to make on this game is Over 47.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Miami Ohio and Holy Cross at Fred C. Yager Stadium is scheduled to start at 1:00 PM ET.

• Who: Holy Cross vs. Miami Ohio
• Date: Saturday, September 12, 2026
• Time: 1:00 PM ET/10:00AM PT
• Venue: Fred C. Yager Stadium

College football Week 2 promos

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Conclusion

We predict Miami Ohio, with a 97.9% win probability, will likely beat Holy Cross in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.