Holy Cross vs. William & Mary prediction: Why William & Mary is favored to win in college football Week 5 [2026]

Using trusted machine learning and data, we have re-simulated the result of Holy Cross vs. William & Mary, forming part of our college football predictions coverage.

Our famous predictive model currently gives William & Mary a 64.2% chance of beating Holy Cross. Our predicted final score has William & Mary winning 29-25. According to our model, Holy Cross (+4.5) has a 51.6% chance of covering the spread, while the 54-point over/under has a 52.3% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Holy Cross +4.5 (-110) / William & Mary -4.5 (-112)
• Moneyline: Holy Cross +175, William & Mary -216
• Total: Over/Under 54 (-115/-107)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Holy Cross +4.5 @ -110 via Caesars
• Moneyline: Holy Cross @ +175 via Caesars
• Total: Over 54 @ -115 via Caesars

According to our college football best bets, the top play to make on this game is Holy Cross to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between William & Mary and Holy Cross at Walter J. Zable Stadium at Cary Field is scheduled to commence at 3:30 PM ET.

• Who: Holy Cross vs. William & Mary
• Date: Saturday, October 3, 2026
• Time: 3:30 PM ET/12:30PM PT
• Venue: Walter J. Zable Stadium at Cary Field

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Conclusion

We predict William & Mary, with a 64.2% win probability, will likely beat Holy Cross in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.