Washington vs. Southern California prediction favors Southern California to win in college football Week 5 [2026]

Using trusted machine learning and statistical analysis, we have re-simulated the outcome of Washington vs. Southern California, forming part of our college football predictions coverage.

Our famous predictive model currently gives Southern California a 72.7% chance of beating Washington. Our predicted final score has Southern California winning 32-25. According to our model, Southern California (-7) has a 51.2% chance of covering the spread, while the 57.5-point over/under has a 51.5% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Washington +7 (-118) / Southern California -7 (-102)
• Moneyline: Washington +270, Southern California -295
• Total: Over/Under 57.5 (-114/-105)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Southern California -7 @ -102 via Caesars
• Moneyline: Washington @ +270 via DraftKings
• Total: Over 57.5 @ -114 via FanDuel

According to our college football best bets, the top play to make on this game is Washington to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between Southern California and Washington at Los Angeles Memorial Coliseum is scheduled to commence at 7:30 PM ET.

• Who: Washington vs. Southern California
• Date: Saturday, October 3, 2026
• Time: 7:30 PM ET/4:30PM PT
• Venue: Los Angeles Memorial Coliseum

College football Week 5 promos

Make the most of Dimers' Washington vs. Southern California predictions by exploring the Underdog Fantasy offer below:

Conclusion

We predict Southern California, with a 72.7% win probability, will likely beat Washington in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.