Iowa State vs. Iowa prediction: Why Iowa is favored to win in college football Week 2 [2026]

Using powerful machine learning and data, we have re-simulated the result of Iowa State vs. Iowa, forming part of our college football predictions coverage.

Our famous predictive model gives Iowa an 87.8% chance of defeating Iowa State. Our predicted final score has Iowa winning 29-14. According to our model, Iowa (-14.5) has a 52.0% chance of covering the spread, while the 41.5-point over/under has a 56.0% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Iowa State +14.5 (-111) / Iowa -14.5 (+100)
• Moneyline: Iowa State +575, Iowa -600
• Total: Over/Under 41.5 (-104/-116)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Iowa -14.5 @ +100 via ESPN BET
• Moneyline: Iowa @ -600 via bet365
• Total: Over 41.5 @ -104 via FanDuel

According to our college football best bets, the top play to make on this game is Over 41.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Iowa and Iowa State at Kinnick Stadium is scheduled to begin at 7:30 PM ET.

• Who: Iowa State vs. Iowa
• Date: Saturday, September 12, 2026
• Time: 7:30 PM ET/4:30PM PT
• Venue: Kinnick Stadium

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Make the most of Dimers' Iowa State vs. Iowa predictions by exploring the Bet365 Sportsbook offer below:

Conclusion

We predict Iowa, with an 87.8% win probability, will likely beat Iowa State in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.