Kentucky vs. South Carolina prediction favors South Carolina to win in college football Week 5 [2026]

Using trusted machine learning and data analysis, we have re-simulated the result of Kentucky vs. South Carolina, forming part of our college football predictions coverage.

Our leading predictive model currently gives South Carolina a 54.1% chance of defeating Kentucky. Our predicted final score has South Carolina winning 27-26. According to our model, Kentucky (+2.5) has a 52.5% chance of covering the spread, while the over/under total of 53 points has a 51.9% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Kentucky +2.5 (-103) / South Carolina -2.5 (-112)
• Moneyline: Kentucky +120, South Carolina -139
• Total: Over/Under 53 (-105/-115)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Kentucky +2.5 @ -103 via Caesars
• Moneyline: Kentucky @ +120 via bet365
• Total: Over 53 @ -105 via bet365

According to our best college football bets, the top play to make on this game is Kentucky +2.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between South Carolina and Kentucky at Williams-Brice Stadium is scheduled to commence at 4:15 PM ET.

• Who: Kentucky vs. South Carolina
• Date: Saturday, October 3, 2026
• Time: 4:15 PM ET/1:15PM PT
• Venue: Williams-Brice Stadium

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Conclusion

We predict South Carolina, with a 54.1% win probability, will likely beat Kentucky in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.