LSU vs. Ole Miss prediction: Why LSU is favored to win in college football Week 3 [2026]

Using trusted machine learning and statistical analysis, we have re-simulated the outcome of LSU vs. Ole Miss, forming part of our college football predictions coverage.

Our leading predictive model gives LSU a 57.6% chance of defeating Mississippi. Our predicted final score has LSU winning 30-27. According to our model, Mississippi (+3.5) has a 54.4% chance of covering the spread, while the over/under total of 58.5 points has a 50.7% chance of staying under.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: LSU -3.5 (+100) / Ole Miss +3.5 (-120)
• Moneyline: LSU -146, Ole Miss +130
• Total: Over/Under 58.5 (-105/-108)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Mississippi +3.5 @ -120 via bet365
• Moneyline: Mississippi @ +130 via bet365
• Total: Under 58.5 @ -108 via Caesars

According to our college football best bets, the top play to make on this game is Mississippi +3.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between Ole Miss and LSU at Vaught-Hemingway Stadium is scheduled to start at 7:30 PM ET.

• Who: LSU vs. Mississippi
• Date: Saturday, September 19, 2026
• Time: 7:30 PM ET/4:30PM PT
• Venue: Vaught-Hemingway Stadium

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Conclusion

We predict LSU, with a 57.6% win probability, will likely beat Mississippi in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.