Southern Illinois vs. Illinois prediction: Why Illinois is favored to win in college football Week 3 [2026]

Using powerful machine learning and data analysis, we have re-simulated the result of Southern Illinois vs. Illinois, forming part of our college football predictions coverage.

Our famous predictive model currently gives Illinois a 99.2% chance of beating Southern Illinois. Our predicted final score has Illinois winning 46-8. According to our model, Southern Illinois (+39.5) has a 53.4% chance of covering the spread, while the 55.5-point over/under has a 54.0% chance of staying under.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Southern Illinois +39.5 (-110) / Illinois -39.5 (-110)
• Moneyline: Southern Illinois , Illinois

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Under @ -110 via Bet365

According to our best college football bets, the top play to make on this game is under 55.5 points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Illinois and Southern Illinois at Gies Memorial Stadium is scheduled to begin at 2:00 PM ET.

• Who: Southern Illinois vs. Illinois
• Date: Saturday, September 19, 2026
• Time: 2:00 PM ET/11:00AM PT
• Venue: Gies Memorial Stadium

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Conclusion

We predict Illinois, with a 99.2% win probability, will likely beat Southern Illinois in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.