Michigan State vs. Notre Dame prediction favors Notre Dame to win in college football Week 3 [2026]

Using innovative machine learning and data, we have re-simulated the result of Michigan State vs. Notre Dame, forming part of our college football predictions coverage.

Our famous predictive model gives Notre Dame a 97.8% chance of defeating Michigan State. Our predicted final score has Notre Dame winning 40-12. According to our model, Michigan State (+29.5) has a 52.1% chance of covering the spread, while the 51.5-point over/under has a 52.9% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Michigan State +29.5 (-109) / Notre Dame -29.5 (-110)
• Moneyline: Michigan State +2400, Notre Dame -5000
• Total: Over/Under 51.5 (-115/-103)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Michigan State +29.5 @ -109 via BetRivers
• Moneyline: Notre Dame @ -5000 via DraftKings
• Total: Over 51.5 @ -115 via bet365

According to our college football best bets, the top play to make on this game is Michigan State +29.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Notre Dame and Michigan State at Notre Dame Stadium is scheduled to start at 7:30 PM ET.

• Who: Michigan State vs. Notre Dame
• Date: Saturday, September 19, 2026
• Time: 7:30 PM ET/4:30PM PT
• Venue: Notre Dame Stadium

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Conclusion

We predict Notre Dame, with a 97.8% win probability, will likely beat Michigan State in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.