Missouri vs. Kansas prediction favors Missouri to win in college football Week 2 [2026]

Using innovative machine learning and statistical analysis, we have re-simulated the outcome of Missouri vs. Kansas, forming part of our college football predictions coverage.

Our independent predictive model currently gives Missouri a 65.7% chance of beating Kansas. Our predicted final score has Missouri winning 28-23. According to our model, Kansas (+5.5) has a 51.1% chance of covering the spread, while the 51.5-point over/under has a 51.7% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Missouri -5.5 (-107) / Kansas +5.5 (-110)
• Moneyline: Missouri -213, Kansas +180
• Total: Over/Under 51.5 (-110/+102)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Kansas +5.5 @ -110 via bet365
• Moneyline: Kansas @ +180 via bet365
• Total: Over 51.5 @ -110 via bet365

According to our college football best bets, the top play to make on this game is Over 51.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Friday's college football matchup between Kansas and Missouri at David Booth Kansas Memorial Stadium is scheduled to commence at 8:00 PM ET.

• Who: Missouri vs. Kansas
• Date: Friday, September 11, 2026
• Time: 8:00 PM ET/5:00PM PT
• Venue: David Booth Kansas Memorial Stadium

College football Week 2 promos

Make the most of Dimers' Missouri vs. Kansas predictions by exploring the Underdog Fantasy offfer below

Conclusion

We predict Missouri, with a 65.7% win probability, will likely beat Kansas in Friday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.