Oregon vs. Ohio State prediction favors Ohio State to win in college football Week 10 [2026]

Using powerful machine learning and data analysis, we have re-simulated the result of Oregon vs. Ohio State, forming part of our college football predictions coverage.

Our leading predictive model gives Ohio State a 74.5% chance of beating Oregon. Our predicted final score has Ohio State winning 27-19. According to our model, Oregon (+13.5) has a 59.2% chance of covering the spread, while the 45.5-point over/under has a 52.4% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Oregon +13.5 (-174) / Ohio State -13.5 (+160)
• Moneyline: Oregon +270, Ohio State -277
• Total: Over/Under 45.5 (+111/-113)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Ohio State -13.5 @ 39¢ via Novig
• Moneyline: Ohio State @ 74¢ via Novig
• Total: Over 45.5 @ 48¢ via Novig

According to our college football best bets, the top play to make on this game is Over 45.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Ohio State and Oregon at Ohio Stadium is scheduled to start at 3:30 PM ET.

• Who: Oregon vs. Ohio State
• Date: Saturday, November 7, 2026
• Time: 3:30 PM ET/12:30 PM PT
• Venue: Ohio Stadium

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Conclusion

We predict Ohio State, with a 74.5% win probability, will likely beat Oregon in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary college football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.