Southeast Missouri State vs. Indiana State prediction: Why Indiana State is favored to win in college football Week 0 [2026]

Indiana State will face Southeast Missouri State in Week 0 college football action at Memorial Stadium on Saturday, with kickoff at 6:00 PM ET.

Dimers' advanced college football model projects Indiana State as the most likely winner in this Southeast Missouri State vs. Indiana State prediction.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, backed by the same system that has dominated college football and NFL betting markets across multiple seasons..

Southeast Missouri State vs. Indiana State prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the result of Southeast Missouri State vs. Indiana State, forming part of our college football predictions coverage.

Our famous predictive model gives Indiana State a 56.4% chance of defeating Southeast Missouri State. Our predicted final score has Indiana State winning 27-24.

According to our model, Indiana State (+1) has a 58.1% chance of covering the spread, while the 53.5-point over/under has a 52.0% chance of staying under.

Southeast Missouri State vs. Indiana State odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Southeast Missouri State -1 (-116) / Indiana State +1 (-116)
• Moneyline: Southeast Missouri State +115, Indiana State -116

All odds are correct at the time of publication and are subject to change.

Southeast Missouri State vs. Indiana State picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Indiana State +1 @ -116 via DraftKings
• Moneyline: Indiana State @ -116 via Fanatics
• Total: Under 53.5 @ -105 via Bet365

According to our college football best bets, the top play to make on this game is Indiana State +1 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Southeast Missouri State vs. Indiana State game-day updates and essential details

Saturday's college football matchup between Indiana State and Southeast Missouri State at Memorial Stadium is scheduled to commence at 6:00 PM ET.

• Who: Southeast Missouri State vs. Indiana State
• Date: Saturday, August 29, 2026
• Time: 6:00 PM ET/3:00PM PT
• Venue: Memorial Stadium

Conclusion

We predict Indiana State, with a 56.4% win probability, will likely beat Southeast Missouri State in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.