Southern Illinois vs. Indiana State prediction: Why Southern Illinois is favored to win in college football Week 10 [2026]

Using trusted machine learning and data, we have re-simulated the result of Southern Illinois vs. Indiana State, forming part of our college football predictions coverage.

Our independent predictive model gives Southern Illinois a 64.6% chance of beating Indiana State. Our predicted final score has Southern Illinois winning 30-25. According to our model, Southern Illinois (-4.5) has a 50.5% chance of covering the spread, while the 57.5-point over/under has a 51.9% chance of staying under.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Southern Illinois -4.5 (+106) / Indiana State +4.5 (-108)
• Moneyline: Southern Illinois -182, Indiana State +164
• Total: Over/Under 57.5 (+113/-113)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Southern Illinois -4.5 @ 48¢ via Novig
• Moneyline: Southern Illinois @ 64¢ via Novig
• Total: Over 57.5 @ 47¢ via Novig

According to our best college football bets, the top play to make on this game is Southern Illinois -4.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between Indiana State and Southern Illinois at Memorial Stadium is scheduled to commence at 6:00 PM ET.

• Who: Southern Illinois vs. Indiana State
• Date: Saturday, November 7, 2026
• Time: 6:00 PM ET/3:00 PM PT
• Venue: Memorial Stadium

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Conclusion

We predict Southern Illinois, with a 64.6% win probability, will likely beat Indiana State in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary college football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.