Stetson vs. South Dakota State prediction: South Dakota State favored to win in college football Week 0 [2026]

South Dakota State will take on Stetson in Week 0 college football action at Dana J. Dykhouse Stadium on Saturday, starting at 7:00 PM ET.

Dimers' proven college football model projects South Dakota State as the most likely winner in this Stetson vs. South Dakota State prediction.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, backed by the same system that has dominated college football and NFL betting markets across multiple seasons..

Stetson vs. South Dakota State prediction: Who will win and cover?

Using powerful machine learning and data analysis, we have simulated the outcome of Stetson vs. South Dakota State, forming part of our college football predictions coverage.

Our independent predictive model gives South Dakota State a 100.0% chance of beating Stetson. Our predicted final score has South Dakota State winning 52-3.

According to our model, Stetson (+51.5) has a 55.0% chance of covering the spread, while the over/under total of 58.5 points has a 56.1% chance of staying under.

Stetson vs. South Dakota State odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Stetson +51.5 (-120) / South Dakota State -51.5 (-110)
• Moneyline: Stetson , South Dakota State

All odds are correct at the time of publication and are subject to change.

Stetson vs. South Dakota State picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Under @ -110 via Bet365

According to our college football best bets, the top play to make on this game is under 58.5 points.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Stetson vs. South Dakota State game-day updates and essential details

Saturday's college football game between South Dakota State and Stetson at Dana J. Dykhouse Stadium is scheduled to begin at 7:00 PM ET.

• Who: Stetson vs. South Dakota State
• Date: Saturday, August 29, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: Dana J. Dykhouse Stadium

Conclusion

We predict South Dakota State, with a 100.0% win probability, will likely beat Stetson in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.