Sep 6, 2026
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Read Article Tulane vs. Duke prediction: Duke favored to win in college football Week 1 [2026]
Updated: | First published:
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Written by Mac Douglass, Senior Editor
Dimers' simulation model projects a 70.5% win probability for Duke at Brooks Field at Wallace Wade Stadium.
Duke will take on Tulane in Week 1 college football action at Brooks Field at Wallace Wade Stadium on Saturday, with kickoff at 3:30 PM ET.
Dimers' advanced college football model projects Duke as the most likely winner in this Tulane vs. Duke prediction.
This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, backed by the same system that has dominated college football and NFL betting markets across multiple seasons.
Tulane vs. Duke prediction and odds
Using trusted machine learning and statistical analysis, we have simulated the outcome of Tulane vs. Duke, forming part of our college football predictions coverage.
Our leading predictive model gives Duke a 70.5% chance of beating Tulane. Our predicted final score has Duke winning 29-21.
According to our model, Tulane (+9.5) has a 52.5% chance of covering the spread, while the 51.5-point over/under has a 53.2% chance of staying under.
Latest betting odds
We have researched the best college football odds in America for this game, which are listed here:
- Spread: Tulane +9.5 (-108) / Duke -9.5 (-110)
- Moneyline: Tulane +300, Duke -303
- Total: Over/Under 51.5 (-105/-105)
All odds are correct at the time of publication and are subject to change.
Model picks and best bet
After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Spread: Tulane +9.5 @ -108 via Caesars
- Moneyline: Tulane @ +300 via DraftKings
- Total: Under 51.5 @ -105 via DraftKings
According to our best college football bets, the top play to make on this game is Tulane to win.
These picks are based on our probabilities matched against the implied probabilities from the current available odds.
Game info & kickoff details
Saturday's college football game between Duke and Tulane at Brooks Field at Wallace Wade Stadium is scheduled to begin at 3:30 PM ET.
- Who: Tulane vs. Duke
- Date: Saturday, September 5, 2026
- Time: 3:30 PM ET/12:30PM PT
- Venue: Brooks Field at Wallace Wade Stadium
College football Week 1 promos
Make the most of Dimers' Tulane vs. Duke predictions by exploring the Underdog Fantasy offfer below
Conclusion
We predict Duke, with a 70.5% win probability, will likely beat Tulane in Saturday's college football matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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