Villanova vs. Louisville prediction favors Louisville to win in college football Week 2 [2026]

Using innovative machine learning and data, we have re-simulated the outcome of Villanova vs. Louisville, forming part of our college football predictions coverage.

Our independent predictive model gives Louisville a 98.5% chance of beating Villanova. Our predicted final score has Louisville winning 45-11. According to our model, Villanova (+36.5) has a 55.9% chance of covering the spread, while the over/under total of 56.5 points has a 50.5% chance of staying under.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Villanova +36.5 (-109) / Louisville -36.5 (-105)
• Moneyline: Villanova +3000, Louisville -10000
• Total: Over/Under 56.5 (-105/-109)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Villanova +36.5 @ -109 via BetRivers
• Moneyline: Louisville @ -10000 via ESPN BET
• Total: Under 56.5 @ -109 via BetRivers

According to our college football best bets, the top play to make on this game is Villanova +36.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Friday's college football action between Louisville and Villanova at L&N Federal Credit Union Stadium is scheduled to begin at 7:00 PM ET.

• Who: Villanova vs. Louisville
• Date: Friday, September 11, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: L&N Federal Credit Union Stadium

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Conclusion

We predict Louisville, with a 98.5% win probability, will likely beat Villanova in Friday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.