Wake Forest vs. Purdue prediction: Why Wake Forest is favored to win in college football Week 2 [2026]

Using trusted machine learning and statistical analysis, we have re-simulated the outcome of Wake Forest vs. Purdue, forming part of our college football predictions coverage.

Our famous predictive model currently gives Wake Forest a 59.0% chance of beating Purdue. Our predicted final score has Wake Forest winning 27-23. According to our model, Wake Forest (-2.5) has a 54.2% chance of covering the spread, while the over/under total of 50.5 points has a 51.8% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Wake Forest -2.5 (-120) / Purdue +2.5 (+100)
• Moneyline: Wake Forest -143, Purdue +130
• Total: Over/Under 50.5 (-107/-109)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Wake Forest -2.5 @ -120 via bet365
• Moneyline: Wake Forest @ -143 via BetRivers
• Total: Over 50.5 @ -107 via Caesars

According to our college football best bets, the top play to make on this game is Wake Forest to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Purdue and Wake Forest at Ross-Ade Stadium is scheduled to start at 12:00 PM ET.

• Who: Wake Forest vs. Purdue
• Date: Saturday, September 12, 2026
• Time: 12:00 PM ET/9:00AM PT
• Venue: Ross-Ade Stadium

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Conclusion

We predict Wake Forest, with a 59.0% win probability, will likely beat Purdue in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.