William & Mary vs. Villanova prediction: Villanova favored to win in college football Week 0 [2026]

Villanova will face William & Mary in Week 0 college football action at Villanova Stadium on Friday, commencing at 6:00 PM ET.

Dimers' advanced college football model projects Villanova as the most likely winner in this William & Mary vs. Villanova prediction.

This article offers a closer look at Friday's matchup, including an expanded look at the predicted score, best bets and picks, backed by the same system that has dominated college football and NFL betting markets across multiple seasons..

William & Mary vs. Villanova prediction: Who will win and cover?

Using trusted machine learning and data analysis, we have simulated the result of William & Mary vs. Villanova, forming part of our college football predictions coverage.

Our independent predictive model currently gives Villanova a 79.2% chance of beating William & Mary. Our predicted final score has Villanova winning 29-18.

According to our model, William & Mary (+13.5) has a 53.1% chance of covering the spread, while the over/under total of 50.5 points has a 57.3% chance of staying under.

William & Mary vs. Villanova odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: William & Mary +13.5 (-110) / Villanova -13.5 (-110)
• Moneyline: William & Mary +462, Villanova -588

All odds are correct at the time of publication and are subject to change.

William & Mary vs. Villanova picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: William & Mary +13.5 @ -110 via DraftKings
• Moneyline: William & Mary @ +462 via DraftKings
• Total: Under 50.5 @ -115 via ESPN BET

According to our college football best bets, the top play to make on this game is Under 50.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

William & Mary vs. Villanova game-day updates and essential details

Friday's college football matchup between Villanova and William & Mary at Villanova Stadium is scheduled to start at 6:00 PM ET.

• Who: William & Mary vs. Villanova
• Date: Friday, August 28, 2026
• Time: 6:00 PM ET/3:00PM PT
• Venue: Villanova Stadium

Conclusion

We predict Villanova, with a 79.2% win probability, will likely beat William & Mary in Friday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.