Orioles vs. Cardinals prediction: St. Louis favored to win Tuesday's MLB matchup [8/25/2026]

MLB action continues on Tuesday at 7:45 PM ET as the Baltimore Orioles lock horns with the St. Louis Cardinals at Busch Stadium.

The Cardinals will have Matthew Liberatore (5-11, 5.04 ERA) as their starting pitcher, while the Orioles are going with Chris Bassitt (4-4, 5.08 ERA).

Dimers' proven MLB model gives the Cardinals a slight edge with a 54.9% win probability over the Orioles.

This article offers a complete Orioles vs. Cardinals prediction, including best bets and picks.

Orioles vs. Cardinals prediction: Who will win and cover?

Using powerful machine learning and data analysis, we have simulated the outcome of Tuesday's MLB game between the Orioles and Cardinals, forming part of our MLB predictions coverage.

Our independent predictive model currently gives the Cardinals a 54.9% chance of beating the Orioles.

According to our model, the Orioles (+1.5) have a 62.2% chance of covering the run line, while the over/under total of 7.5 runs has a 58.6% chance of going over.

Orioles vs. Cardinals odds [8/25/2026]

We have sourced the best MLB odds in America for this game, which are listed here:

• Run Line: Orioles +1.5 (-182) / Cardinals -1.5 (+178)
• Moneyline: Orioles +115, Cardinals -115

All odds are correct at the time of publication and are subject to change.

Orioles vs. Cardinals picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Run line: Cardinals -1.5 @ +178 via DraftKings
• Moneyline: Cardinals @ -115 via Novig
• Total: Over 7.5 @ -111 via Novig

According to our MLB best bets, the top play to make on this game is Over 7.5 total runs.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Orioles vs. Cardinals game-day updates and essential details

Tuesday's MLB game between the Cardinals and Orioles at Busch Stadium is scheduled to commence at 7:45 PM ET.

• Who: Baltimore Orioles vs. St. Louis Cardinals
• Date: Tuesday, August 25, 2026
• Time: 7:45 PM ET/4:45PM PT
• Venue: Busch Stadium

Conclusion

We predict the Cardinals, with a 54.9% win probability, will likely beat the Orioles in Tuesday's MLB matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.