Aug 25, 2026
Astros vs. Yankees prediction: Yankees favored to win Tuesday's MLB matchup [8/25/2026]
Read Article Orioles vs. Cardinals prediction: St. Louis favored to win Tuesday's MLB matchup [8/25/2026]
Updated: | First published:
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Written by Dave Garofolo, Content Producer
Get Baltimore Orioles vs St. Louis Cardinals predictions for MLB Tuesday.
The St. Louis Cardinals and Baltimore Orioles will meet in MLB action at Busch Stadium on Tuesday, starting at 7:45 PM ET.
Matthew Liberatore (5-11, 5.04 ERA) will get the ball for the Cardinals, pitting him against Chris Bassitt (4-4, 5.08 ERA) for the Orioles.
Dimers' advanced MLB model projects the Cardinals as the most likely winner in this Orioles vs. Cardinals prediction.
This article offers an expanded analysis of Tuesday's matchup, including best bets and picks.
Orioles vs. Cardinals prediction: Who will win and cover?
Using innovative machine learning and data, we have simulated the outcome of Tuesday's MLB matchup between the Orioles and Cardinals, forming part of our MLB predictions coverage.
Our famous predictive model gives the Cardinals a 55.1% chance of defeating the Orioles.
According to our model, the Orioles (+1.5) have a 62.0% chance of covering the run line, while the 8.5-run over/under has a 55.4% chance of going over.
Orioles vs. Cardinals odds [8/25/2026]
We have researched the best MLB odds in America for this game, which are listed here:
- Run Line: Orioles +1.5 (-178) / Cardinals -1.5 (+170)
- Moneyline: Orioles +117, Cardinals -120
All odds are correct at the time of publication and are subject to change.
Orioles vs. Cardinals picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Cardinals -1.5 @ +170 via DraftKings
- Moneyline: Cardinals @ -120 via Bet365
- Total: Over 8.5 @ -106 via Novig
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Orioles vs. Cardinals game-day updates and essential details
Tuesday's MLB action between the Cardinals and Orioles at Busch Stadium is scheduled to start at 7:45 PM ET.
- Who: Baltimore Orioles vs. St. Louis Cardinals
- Date: Tuesday, August 25, 2026
- Time: 7:45 PM ET/4:45PM PT
- Venue: Busch Stadium
Conclusion
We predict the Cardinals, with a 55.1% win probability, will likely beat the Orioles in Tuesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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