Orioles vs. Cardinals prediction: Baltimore favored to win Wednesday's MLB matchup [8/26/2026]

The St. Louis Cardinals and Baltimore Orioles will lock horns in MLB action at Busch Stadium on Wednesday, starting at 7:45 PM ET.

Michael McGreevy (5-9, 3.54 ERA) will start on the mound for the Cardinals, while the Orioles have opted for Kyle Bradish (7-12, 3.70 ERA).

Dimers' proven MLB model gives the Orioles a slight edge with a 50.1% win probability over the Cardinals.

This article offers a complete Orioles vs. Cardinals prediction, including best bets and picks.

Orioles vs. Cardinals prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the result of Wednesday's MLB matchup between the Orioles and Cardinals, forming part of our MLB predictions coverage.

Our famous predictive model currently gives the Orioles a 50.1% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 61.9% chance of covering the run line, while the over/under total of 8.5 runs has a 53.1% chance of going over.

Orioles vs. Cardinals odds [8/26/2026]

We have researched the best MLB odds in America for this game, which are listed here:

• Run Line: Orioles -1.5 (+163) / Cardinals +1.5 (-163)
• Moneyline: Orioles -104, Cardinals +102

All odds are correct at the time of publication and are subject to change.

Orioles vs. Cardinals picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Run line: Orioles -1.5 @ +163 via DraftKings
• Moneyline: Cardinals @ +102 via Novig
• Total: Over 8.5 @ +104 via Novig

According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Orioles vs. Cardinals game-day updates and essential details

Wednesday's MLB action between the Cardinals and Orioles at Busch Stadium is scheduled to begin at 7:45 PM ET.

• Who: Baltimore Orioles vs. St. Louis Cardinals
• Date: Wednesday, August 26, 2026
• Time: 7:45 PM ET/4:45PM PT
• Venue: Busch Stadium

Conclusion

We predict the Orioles, with a 50.1% win probability, will likely beat the Cardinals in Wednesday's MLB matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.