Red Sox vs. Yankees prediction: Yankees favored to win Friday's MLB matchup [8/28/2026]

The New York Yankees will take on the Boston Red Sox in MLB action at Yankee Stadium on Friday, commencing at 7:15 PM ET.

Cam Schlittler (11-6, 2.16 ERA) will start for the Yankees, while the Red Sox have opted for Patrick Sandoval (1-2, 4.54 ERA).

Dimers' advanced MLB model projects the Yankees as the most likely winner in this Red Sox vs. Yankees prediction.

This article offers a closer look at Friday's matchup, including best bets and picks.

For more, dive into Cam Schlittler's pitching projections.

Red Sox vs. Yankees prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Friday's MLB matchup between the Red Sox and Yankees, forming part of our MLB predictions coverage.

Our independent predictive model gives the Yankees a 59.7% chance of beating the Red Sox.

According to our model, the Red Sox (+1.5) have a 56.9% chance of covering the run line, while the 7.5-run over/under has a 54.6% chance of going over.

Red Sox vs. Yankees odds [8/28/2026]

We have researched the best MLB odds in America for this game, which are listed here:

• Run Line: Red Sox +1.5 (-155) / Yankees -1.5 (+150)
• Moneyline: Red Sox +142, Yankees -141

All odds are correct at the time of publication and are subject to change.

Red Sox vs. Yankees picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Run line: Yankees -1.5 @ +150 via DraftKings
• Moneyline: Yankees @ -141 via Novig
• Total: Over 7.5 @ +127 via Novig

According to our MLB best bets, the top play to make on this game is Over 7.5 total runs.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Red Sox vs. Yankees game-day updates and essential details

Friday's MLB matchup between the Yankees and Red Sox at Yankee Stadium is scheduled to commence at 7:15 PM ET.

• Who: Boston Red Sox vs. New York Yankees
• Date: Friday, August 28, 2026
• Time: 7:15 PM ET/4:15PM PT
• Venue: Yankee Stadium

Conclusion

We predict the Yankees, with a 59.7% win probability, will likely beat the Red Sox in Friday's MLB matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.