Cubs vs. Diamondbacks prediction: Why Arizona is favored to win Tuesday's MLB matchup [8/25/2026]

MLB action continues on Tuesday at 9:40 PM ET as the Chicago Cubs take on the Arizona Diamondbacks at Chase Field.

The Diamondbacks will start Brandon Pfaadt (7-1, 3.39 ERA), pitting him against Clay Holmes (5-6, 2.49 ERA) for the Cubs.

Dimers' proven MLB model gives the Diamondbacks a slight edge with a 50.6% win probability over the Cubs.

This article offers a complete Cubs vs. Diamondbacks prediction, including best bets and picks.

Cubs vs. Diamondbacks prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the result of Tuesday's MLB matchup between the Cubs and Diamondbacks, forming part of our MLB predictions coverage.

Our independent predictive model currently gives the Diamondbacks a 50.6% chance of defeating the Cubs.

According to our model, the Diamondbacks (+1.5) have a 62.4% chance of covering the run line, while the 8.5-run over/under has a 58.1% chance of going over.

Cubs vs. Diamondbacks odds [8/25/2026]

We have sourced the best MLB odds in America for this game, which are listed here:

• Run Line: Cubs -1.5 (+163) / Diamondbacks +1.5 (-167)
• Moneyline: Cubs +105, Diamondbacks -102

All odds are correct at the time of publication and are subject to change.

Cubs vs. Diamondbacks picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Run line: Diamondbacks +1.5 @ -167 via DraftKings
• Moneyline: Cubs @ +105 via DraftKings
• Total: Over 8.5 @ +108 via Novig

According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Cubs vs. Diamondbacks game-day updates and essential details

Tuesday's MLB game between the Diamondbacks and Cubs at Chase Field is scheduled to begin at 9:40 PM ET.

• Who: Chicago Cubs vs. Arizona Diamondbacks
• Date: Tuesday, August 25, 2026
• Time: 9:40 PM ET/6:40PM PT
• Venue: Chase Field

Conclusion

We predict the Diamondbacks, with a 50.6% win probability, will likely beat the Cubs in Tuesday's MLB matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.