Aug 25, 2026
Rangers vs. White Sox prediction: Why Texas is favored to win Tuesday's MLB matchup [8/25/2026]
Read Article Cubs vs. Diamondbacks prediction: Why Arizona is favored to win Tuesday's MLB matchup [8/25/2026]
Updated: | First published:
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Written by Dave Garofolo, Content Producer
Get Chicago Cubs vs Arizona Diamondbacks predictions for MLB Tuesday.
The Arizona Diamondbacks and Chicago Cubs will meet in MLB action at Chase Field on Tuesday, starting at 9:40 PM ET.
The Diamondbacks will send Brandon Pfaadt (7-1, 3.39 ERA) to the mound, pitting him against Clay Holmes (5-6, 2.49 ERA) for the Cubs.
Dimers' advanced MLB model gives the Diamondbacks a slight edge with a 50.5% win probability over the Cubs.
This article offers a complete Cubs vs. Diamondbacks prediction, including best bets and picks.
Cubs vs. Diamondbacks prediction: Who will win and cover?
Using powerful machine learning and data, we have simulated the outcome of Tuesday's MLB matchup between the Cubs and Diamondbacks, forming part of our MLB predictions coverage.
Our famous predictive model currently gives the Diamondbacks a 50.5% chance of beating the Cubs.
According to our model, the Diamondbacks (+1.5) have a 62.0% chance of covering the run line, while the 8.5-run over/under has a 57.9% chance of going over.
Cubs vs. Diamondbacks odds [8/25/2026]
We have researched the best MLB odds in America for this game, which are listed here:
- Run Line: Cubs -1.5 (+160) / Diamondbacks +1.5 (-163)
- Moneyline: Cubs -104, Diamondbacks +104
All odds are correct at the time of publication and are subject to change.
Cubs vs. Diamondbacks picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Diamondbacks +1.5 @ -163 via DraftKings
- Moneyline: Diamondbacks @ +104 via Polymarket
- Total: Over 8.5 @ +111 via Novig
According to our best MLB bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cubs vs. Diamondbacks game-day updates and essential details
Tuesday's MLB action between the Diamondbacks and Cubs at Chase Field is scheduled to start at 9:40 PM ET.
- Who: Chicago Cubs vs. Arizona Diamondbacks
- Date: Tuesday, August 25, 2026
- Time: 9:40 PM ET/6:40PM PT
- Venue: Chase Field
Conclusion
We predict the Diamondbacks, with a 50.5% win probability, will likely beat the Cubs in Tuesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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