Aug 26, 2026
Red Sox vs. Marlins prediction: Why Boston is favored to win Wednesday's MLB matchup [8/26/2026]
Read Article Cubs vs. Diamondbacks prediction: Why Arizona is favored to win Wednesday's MLB matchup [8/26/2026]
Updated: | First published:
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Written by Dave Garofolo, Content Producer
Get Chicago Cubs vs Arizona Diamondbacks predictions for MLB Wednesday.
The Arizona Diamondbacks and Chicago Cubs will lock horns in MLB action at Chase Field on Wednesday, starting at 3:40 PM ET.
Eduardo Rodriguez (13-4, 2.61 ERA) will be the starting pitcher for the Diamondbacks, pitting him against Matthew Boyd (8-2, 4.15 ERA) for the Cubs.
Dimers' proven MLB model gives the Diamondbacks a slight edge with a 51.5% win probability over the Cubs.
This article offers a complete Cubs vs. Diamondbacks prediction, including best bets and picks.
Cubs vs. Diamondbacks prediction: Who will win and cover?
Using innovative machine learning and statistical analysis, we have simulated the outcome of Wednesday's MLB game between the Cubs and Diamondbacks, forming part of our MLB predictions coverage.
Our famous predictive model currently gives the Diamondbacks a 51.5% chance of beating the Cubs.
According to our model, the Cubs (+1.5) have a 64.5% chance of covering the run line, while the 8.5-run over/under has a 61.4% chance of going over.
Cubs vs. Diamondbacks odds [8/26/2026]
We have researched the best MLB odds in America for this game, which are listed here:
- Run Line: Cubs +1.5 (-220) / Diamondbacks -1.5 (+180)
- Moneyline: Cubs +101, Diamondbacks +100
All odds are correct at the time of publication and are subject to change.
Cubs vs. Diamondbacks picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Diamondbacks -1.5 @ +180 via DraftKings
- Moneyline: Diamondbacks @ +100 via Polymarket
- Total: Over 8.5 @ -113 via Polymarket
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cubs vs. Diamondbacks game-day updates and essential details
Wednesday's MLB action between the Diamondbacks and Cubs at Chase Field is scheduled to begin at 3:40 PM ET.
- Who: Chicago Cubs vs. Arizona Diamondbacks
- Date: Wednesday, August 26, 2026
- Time: 3:40 PM ET/12:40PM PT
- Venue: Chase Field
Conclusion
We predict the Diamondbacks, with a 51.5% win probability, will likely beat the Cubs in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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