Cubs vs. Diamondbacks prediction: Why Cubs are favored to win Wednesday's MLB matchup [8/26/2026]

The Arizona Diamondbacks will face the Chicago Cubs, in what is expected to be a close MLB game, at Chase Field on Wednesday, commencing at 3:40 PM ET.

The Diamondbacks will send Eduardo Rodriguez (13-4, 2.61 ERA) to the mound, pitting him against Matthew Boyd (8-2, 4.15 ERA) for the Cubs.

Dimers' proven MLB model gives the Cubs a slight edge with a 51.2% win probability over the Diamondbacks.

This article offers a complete Cubs vs. Diamondbacks prediction, including best bets and picks.

Cubs vs. Diamondbacks prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the result of Wednesday's MLB matchup between the Cubs and Diamondbacks, forming part of our MLB predictions coverage.

Our independent predictive model currently gives the Cubs a 51.2% chance of defeating the Diamondbacks.

According to our model, the Diamondbacks (+1.5) have a 60.7% chance of covering the run line, while the 8.5-run over/under has a 58.2% chance of going over.

Cubs vs. Diamondbacks odds [8/26/2026]

We have sourced the best MLB odds in America for this game, which are listed here:

• Run Line: Cubs -1.5 (+147) / Diamondbacks +1.5 (-150)
• Moneyline: Cubs -108, Diamondbacks +110

All odds are correct at the time of publication and are subject to change.

Cubs vs. Diamondbacks picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Run line: Diamondbacks +1.5 @ -150 via DraftKings
• Moneyline: Diamondbacks @ +110 via Bet365
• Total: Over 8.5 @ +108 via Novig

According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Cubs vs. Diamondbacks game-day updates and essential details

Wednesday's MLB matchup between the Diamondbacks and Cubs at Chase Field is scheduled to begin at 3:40 PM ET.

• Who: Chicago Cubs vs. Arizona Diamondbacks
• Date: Wednesday, August 26, 2026
• Time: 3:40 PM ET/12:40PM PT
• Venue: Chase Field

Conclusion

We predict the Cubs, with a 51.2% win probability, will likely beat the Diamondbacks in Wednesday's MLB matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.